Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.

  title={Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.},
  author={Yuanmei Lou and Olena Preobrazhenska and Ulrich Auf dem Keller and Margaret Sutcliffe and Lorena Barclay and Paul C. McDonald and Calvin D Roskelley and Christopher M. Overall and Shoukat Dedhar},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={237 10},
Epithelial-mesenchymal transition (EMT) has been linked to metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in vivo metastatic ability. Contrary to expectations, 67NR cells, which form primary tumors but fail to metastasize, express vimentin and N-cadherin, but not E-cadherin. 4T1 cells express E-cadherin and ZO-1, but are migratory, invasive, and… CONTINUE READING

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