Epithelial junctions maintain tissue architecture by directing planar spindle orientation

@article{Nakajima2013EpithelialJM,
  title={Epithelial junctions maintain tissue architecture by directing planar spindle orientation},
  author={Y. Nakajima and Emily J. Meyer and Amanda E Kroesen and S. McKinney and M. Gibson},
  journal={Nature},
  year={2013},
  volume={500},
  pages={359-362}
}
During epithelial cell proliferation, planar alignment of the mitotic spindle coordinates the local process of symmetric cell cleavage with the global maintenance of polarized tissue architecture. Although the disruption of planar spindle alignment is proposed to cause epithelial to mesenchymal transition and cancer, the in vivo mechanisms regulating mitotic spindle orientation remain elusive. Here we demonstrate that the actomyosin cortex and the junction-localized neoplastic tumour… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Planar Spindle Orientation and Asymmetric Cytokinesis in the Mouse Small Intestine
Epithelial cell polarity: a major gatekeeper against cancer?
  • C. Royer, X. Lu
  • Biology, Medicine
  • Cell Death and Differentiation
  • 2011
Rho overexpression leads to mitosis-associated detachment of cells from epithelial sheets: a link to the mechanism of cancer dissemination.
Cell Division Orientation in Animals
...
1
2
3
4
5
...