Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair.

@article{Young1993EpithelialfibroblastII,
  title={Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair.},
  author={Lei Young and Ian Y. R. Adamson},
  journal={Environmental Health Perspectives},
  year={1993},
  volume={101},
  pages={56 - 61}
}
Intercellular communication between epithelial cells and fibroblasts of the alveolar wall contributes to regulatory control of each cell type. We examined whether lung injury and subsequent fibrosis are associated with disturbance of this mutual control system. Rats received bleomycin intratracheally, and after 10 days, when acute epithelial injury occurs, and at 6 weeks, when repair with fibrosis is found, pure populations of type 2 epithelial cells and lung fibroblasts were prepared to study… CONTINUE READING
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Recipro - cal epithelial : fibroblast interactions in the control of fetal and adult rat lung cells in culture

  • Adamson IYR, L Young, GM King
  • Exp Lung Res
  • 1991

Alveolar injury and repair

  • Adamson IYR
  • Electron microscopy of the lung ( Schraufnagel DE…
  • 1990

Alveolar epithelium inhibits interstitial cell proliferation by the production of a low molecular weight lipid soluble factor ( s )

  • JH Hunter, RK Merchant, G Hunninghake
  • Am Rev Respir Dis
  • 1989