Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair.

  title={Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair.},
  author={Lei Young and Ian Y. R. Adamson},
  journal={Environmental Health Perspectives},
  pages={56 - 61}
Intercellular communication between epithelial cells and fibroblasts of the alveolar wall contributes to regulatory control of each cell type. We examined whether lung injury and subsequent fibrosis are associated with disturbance of this mutual control system. Rats received bleomycin intratracheally, and after 10 days, when acute epithelial injury occurs, and at 6 weeks, when repair with fibrosis is found, pure populations of type 2 epithelial cells and lung fibroblasts were prepared to study… CONTINUE READING
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