Epithelial decision makers: in search of the 'epimmunome'

  title={Epithelial decision makers: in search of the 'epimmunome'},
  author={Mahima Swamy and Colin Jamora and Wendy L. Havran and Adrian C. Hayday},
  journal={Nature Immunology},
Frequent microbial and nonmicrobial challenges to epithelial cells trigger discrete pathways, promoting molecular changes such as the secretion of specific cytokines and chemokines and alterations to molecules displayed at the epithelial cell surface. In combination, these molecules impose key decisions on innate and adaptive immune cells. Depending on context, those decisions can be as diverse as those imposed by professional antigen-presenting cells, benefiting the host by balancing immune… CONTINUE READING

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