Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer.

  title={Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer.},
  author={Saman A Arbabi and Matthew Randall Rosengart and Iris A. Garc{\'i}a and Sandra Jelacic and Ronald V. Maier},
  journal={The Journal of surgical research},
  volume={97 1},
BACKGROUND Recent studies indicate a close relationship between cyclooxygense-2 (COX-2) expression and the pathogenesis of colorectal cancer, yet little information exists regarding the stimuli and pathways involved in COX-2 expression by the colonic epithelium. We studied the induction of COX-2 in response to such environmental stress as hyperosmolarity and lipopolysaccharide (LPS) in a human colon cell line. We further investigated the transduction cascades mediating COX-2 expression… CONTINUE READING


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