Epithelial crosstalk at the microbiota-mucosal interface.

  title={Epithelial crosstalk at the microbiota-mucosal interface.},
  author={Jerry M. Wells and Oriana Rossi and Marjolein Meijerink and Peter van Baarlen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 Suppl 1},
This article provides an overview of how intestinal epithelial cells (IEC) recognize commensals and how they maintain host-bacterial symbiosis. Endocrine, goblet cells, and enterocytes of the intestinal epithelium express a range of pattern recognition receptors (PRR) to sense the presence of microbes. The best characterized are the Toll-like receptors (TLR) and nucleotide oligomerization domain-like receptors (NLR), which play a key role in pathogen recognition and the induction of innate… CONTINUE READING
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