Epithelial chloride channel. Development of inhibitory ligands

  title={Epithelial chloride channel. Development of inhibitory ligands},
  author={Donald W. Landry and Marc Reitman and Edward J. Cragoe and Qais Al-Awqati},
  journal={The Journal of General Physiology},
  pages={779 - 798}
Chloride channels are present in the majority of epithelial cells, where they mediate absorption or secretion of NaCl. Although the absorptive and secretory channels are well characterized in terms of their electrophysiological behavior, there is a lack of pharmacological ligands that can aid us in further functional and eventually molecular characterization. To obtain such ligands, we prepared membrane vesicles from bovine kidney cortex and apical membrane vesicles from trachea and found that… CONTINUE READING
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CI - channel blockers in the thick ascending limb of the loop of Henle . Structure activity relationship

  • P. Wangemann, H. Wittner, +4 authors R. Greger
  • Pflf , gers Archiv .
  • 1986
Highly Influential
13 Excerpts

The Na : K : 2 CI cotransporter in epithelia

  • S. O'Grady, C. Palfrey, M. Field
  • American Journal of Physiology .
  • 1987
1 Excerpt

Ca channels in intact cardiac cells : voltage - dependent effects and cooperative interactions of dihydropyridine enantiomers

  • S. Kokubun, B. Prod'horn, C. Becker, H. Porzig, H. Reuter
  • Molecular Pharmacology .
  • 1986
1 Excerpt

Ionic conductances of apical and basal cell membranes of collecting duct principal cells in culture

  • W. Minuth, E. Fromter
  • Kidney International .
  • 1986

Potassium and chloride channels in the luminal and basolateral membranes of Amphiuma early distal tubules

  • M. Hunter, G. Giebisch
  • Kidney International .
  • 1986

The significance of the relative effects of loop diuretics and anti - brain edema agents on the Na + , K § CI - cotransport system and the CI - / NaCO ~ anion exchanger

  • P. A. Hannaert, C. Nazaret, E. J. Cragoe
  • Naunyn - Schmiedeberg ' s Archivffir…
  • 1986

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