Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells

@article{Londei1984EpithelialCE,
  title={Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells},
  author={Marco Londei and Jonathan Robert Lamb and Gian Franco Bottazzo and Marc Feldmann},
  journal={Nature},
  year={1984},
  volume={312},
  pages={639-641}
}
The first step in the induction of immune responses, whether humoral or cell mediated, requires the interaction between antigen-presenting cells and T lymphocytes restricted at the major histo-compatibility complex (MHC)1,2. These cells invariably express MHC class II molecules (HLA-D region in man and Ia in mouse) which are recognized by T cells of the helper/inducer subset in association with antigen fragments3,4. Interestingly, in certain pathological conditions5–8, for example in autoimmune… CONTINUE READING