Epithelial cells as immune effector cells: the role of CD40.


Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts.

DOI: 10.1016/j.smim.2009.06.002

Cite this paper

@article{Dugger2009EpithelialCA, title={Epithelial cells as immune effector cells: the role of CD40.}, author={Kari J Dugger and Thomas W. Lowder and Torry A. Tucker and Lisa M. Schwiebert}, journal={Seminars in immunology}, year={2009}, volume={21 5}, pages={289-92} }