Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

@article{Artis2008EpithelialcellRO,
  title={Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut},
  author={David Artis},
  journal={Nature Reviews Immunology},
  year={2008},
  volume={8},
  pages={411-420}
}
Mucosal surfaces such as the intestinal tract are continuously exposed to both potential pathogens and beneficial commensal microorganisms. This creates a requirement for a homeostatic balance between tolerance and immunity that represents a unique regulatory challenge to the mucosal immune system. Recent findings suggest that intestinal epithelial cells, although once considered a simple physical barrier, are a crucial cell lineage for maintaining intestinal immune homeostasis. This Review… CONTINUE READING
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