Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors.

Cell migration plays a central role in a wide variety of biological events, including embryogenesis, inflammatory immune response, wound healing, or cancer invasion. Tight regulation of cell motility is a prerequisite for normal development and maintenance of an organism, and to avoid metastatic spread of tumor cells. An important determinant of migratory… CONTINUE READING