Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon.

@article{Whorwood1994EpithelialCL,
  title={Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon.},
  author={Christopher B Whorwood and Marie Louise Ricketts and P. M. Stewart},
  journal={Endocrinology},
  year={1994},
  volume={135 6},
  pages={2533-41}
}
11 beta-Hydroxysteroid dehydrogenase (11 beta HSD), by catalyzing the interconversion of active corticosterone (B) to inactive 11-dehydrocorticosterone (A) in the rat and cortisol (F) to cortisone in man, maintains normal in vivo specificity of the mineralocorticoid receptor (MR) in both kidney and distal colon. Two isoforms of 11 beta HSD have been reported: the cloned type I, NADP(H)-dependent 11 beta-dehydrogenase/oxo-reductase, and a high affinity NAD+-dependent 11 beta-dehydrogenase (type… CONTINUE READING
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