Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.

@article{Seydel1998EpithelialCI,
  title={Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.},
  author={Karl Seydel and Erqiu Li and Zhenshu Zhang and Samuel L. Stanley},
  journal={Gastroenterology},
  year={1998},
  volume={115 6},
  pages={1446-53}
}
BACKGROUND & AIMS Entamoeba histolytica infection of the intestine can induce severe gut inflammation. The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response. METHODS E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice. Human intestinal epithelial cell inflammatory responses… CONTINUE READING
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