Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling.

  title={Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling.},
  author={Stephan Busche and Arnaud Descot and Sylvia Julien and Harald Genth and Guido Posern},
  journal={Journal of cell science},
  volume={121 Pt 7},
Epithelial cell-cell junctions are specialised structures connecting individual cells in epithelial tissues. They are dynamically and functionally linked to the actin cytoskeleton. Disassembly of these junctions is a key event during physiological and pathological processes, but how this influences gene expression is largely uncharacterised. Here, we investigate whether junction disassembly regulates transcription by serum response factor (SRF) and its coactivator MAL/MRTF. Ca2+-dependent… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 41 extracted citations

The fate of the primary cilium during myofibroblast transition

Molecular biology of the cell • 2014
View 5 Excerpts
Highly Influenced

MRTFs- master regulators of EMT.

Developmental dynamics : an official publication of the American Association of Anatomists • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…