Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa.

@article{Mizumori2006EpithelialCA,
  title={Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa.},
  author={Misa Mizumori and Justin Gabriel Meyerowitz and Tetsu Takeuchi and Shu Hui Lim and Paul Ung-Joon Lee and Claudiu T. Supuran and Paul H. Guth and Eli Engel and Jonathan D Kaunitz and Yasutada Akiba},
  journal={The Journal of physiology},
  year={2006},
  volume={573 Pt 3},
  pages={827-42}
}
The duodenum is the site of mixing of massive amounts of gastric H+ with secreted HCO3-, generating CO2 and H2O accompanied by the neutralization of H+. We examined the role of membrane-bound and soluble carbonic anhydrases (CA) by which H+ is neutralized, CO2 is absorbed, and HCO3- is secreted. Rat duodena were perfused with solutions of different pH and PCO2 with or without a cell-permeant CA inhibitor methazolamide (MTZ) or impermeant CA inhibitors. Flow-through pH and PCO2 electrodes… CONTINUE READING

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