Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development.


Renal fibrosis is the common anatomical feature underlying the progression of chronic kidney disease, a leading cause of morbidity and mortality worldwide. In a previous study, we demonstrated that during development of renal fibrosis in a rat model of unilateral ureteric obstruction, calreticulin (CRT) is up-regulated in tubular epithelial cells (TECs). In… (More)
DOI: 10.1016/j.ajpath.2013.07.014

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