Epithelial and fibroblast cell lines derived from a spontaneous mammary carcinoma in a MMTV/neu transgenic mouse

@article{Campbell2002EpithelialAF,
  title={Epithelial and fibroblast cell lines derived from a spontaneous mammary carcinoma in a MMTV/neu transgenic mouse},
  author={M J Campbell and Wendy S. Wollish and Margaret M Lobo and Laura Esserman},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2002},
  volume={38},
  pages={326-333}
}
Female murine mammary tumor virus (MMTV)/neu transgenic mice, expressing a wild-type rat neu oncogene driven by an MMTV promoter, develop focal mammary adenocarcinomas that are pathologically very similar to human breast tumors. Two new cell lines were established from a mammary tumor that arose in a female MMTV/neu transgenic mouse. One of these lines, mammary carcinoma from Neu transgenic mouse A (MCNeuA), has an epithelial morphology, is cytokeratin positive, and expresses high levels of the… CONTINUE READING
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