Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions.

@article{Streeck2011EpithelialAM,
  title={Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions.},
  author={Hendrik Streeck and Douglas S Kwon and Augustine Pyo and Michael E Flanders and Mathieu F Chevalier and Kenneth Law and Boris Dominik J{\"u}lg and Kasper Trocha and Jonathan S. Jolin and Melis N Anahtar and Jeff Lian and Ildik{\'o} Horv{\'a}thn{\'e} T{\'o}th and Zabrina L. Brumme and Judy J Chang and Tyler J Caron and Scott J Rodig and Danny Arnold Milner and Alicja Piechoka-Trocha and Daniel E Kaufmann and Bruce D. Walker and Marcus Altfeld},
  journal={Blood},
  year={2011},
  volume={117 19},
  pages={
          5112-22
        }
}
Under persistent antigenic stimulation, virus-specific CD8⁺ T cells become increasingly dysfunctional and up-regulate several inhibitory molecules such as killer lectin-like receptor G1 (KLRG1). Here, we demonstrate that HIV-1 antigen-specific T cells from subjects with chronic-progressive HIV-1 infection have significantly elevated KLRG1 expression (P < .001); show abnormal distribution of E-cadherin, the natural ligand of KLRG1, in the intestinal mucosa; and have elevated levels of systemic… CONTINUE READING

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