Epithelial-Mesenchymal Transitions in Development and Disease

  title={Epithelial-Mesenchymal Transitions in Development and Disease},
  author={Jean Paul Thiery and Herv{\'e} Acloque and Ruby Y.J. Huang and M Angela Nieto},
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is… CONTINUE READING
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