Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness

@inproceedings{Li2011EpithelialHE,
  title={Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness},
  author={Xiaohong Li and M. Angeles Mart{\'i}nez-Ferrer and Vincent Botta and Consolate Uwamariya and Jheelam Banerjee and Neil A. Bhowmick},
  booktitle={Oncogene},
  year={2011}
}
Stromal–epithelial interactions dictate prostate tumorigenesis and response to castration. Hydrogen peroxide-inducible clone 5 (Hic-5/ARA55) is a transforming growth factor-beta (TGF-β)-induced coactivator of androgen receptor (AR) expressed in the prostate stroma. Interestingly, following castration, we identified epithelial expression of Hic-5/ARA55 in mouse and human prostate tissues. To determine the role of epithelial Hic-5 in prostate cancer progression and castration responsiveness, we… CONTINUE READING
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