• DOI:10.1097/ICO.0b013e31826905b3
• Corpus ID: 37848356

Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Oral Nutritional Supplements Before and After Photorefractive Keratectomy: A Pilot Study

@article{Ong2013EpithelialHA,
  title={Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Oral Nutritional Supplements Before and After Photorefractive Keratectomy: A Pilot Study},
  author={Nikki Heidi Ong and Tracy L. Purcell and Anne-Catherine Roch-Levecq and Dorothy Wei Yun Wang and M. A. Isidro and K{\'a}tia Mantovani Bott{\'o}s and Christopher W D Heichel and David J. Schanzlin},
  journal={Cornea},
  year={2013},
  volume={32},
  pages={761–765}
}

• Nikki Heidi Ong, T. Purcell, +5 authors D. Schanzlin
• Published 1 June 2013
• Medicine
• Cornea

Purpose: To investigate the effect of omega-3 oral nutritional supplementation on corneal reepithelialization, visual acuity, and tear stability after photorefractive keratectomy (PRK). Methods: This is a prospective, randomized, single-blinded controlled therapeutic trial using omega-3 oral nutritional supplements (TheraTears Nutrition for Dry Eyes; Advanced Vision Research—Akorn, Ann Arbor, MI) conducted at our center. Eighteen healthy patients with refractive error between −1 and −8 diopters were recruited and had bilateral PRK. The treatment group (n = 9 subjects) received omega-3 2 weeks before surgery through 1 month after PRK. The control group (n = 9 subjects) was not given omega-3. Epithelial defects were photographed on postoperative days 0 to 5. Reepithelialization (area in square millimeters) was assessed by fluorescein staining until healing. Tear breakup time (TBUT) and uncorrected distance visual acuity were measured at 1 week, and 1 and 3 months postoperatively. Results: Epithelial defect in the treatment group eyes healed faster compared with that of the controls (P = 0.04). The treatment group eyes healed at an average rate of 1.19% [SD = 0.002; 95% confidence interval (CI), 1.04%–1.34%] per hour, versus 0.83% (SD = 0.0008; 95% CI, 0.77%–0.89%) for controls (Mann–Whitney rank-sum test, P < 0.001). The treatment group eyes maintained a significantly longer TBUT from week 1 through 3 months (mean = 9.52 seconds, SD = 0.81; 95% CI, 8.93–10.10), compared with the controls (mean = 5.52 seconds, SD = 0.81; 95% CI, 4.93–6.10; P < 0.001), and all reached 20/20 vision versus only 4 in the control group 1 month after surgery (P = 0.03). Conclusions: Omega-3 oral nutritional supplements decreased the average time for epithelial healing, and improved TBUT and visual acuity recovery in PRK. These findings suggested that omega-3 oral nutritional supplementation may be a beneficial adjunct therapy for PRK patients.