Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Oral Nutritional Supplements Before and After Photorefractive Keratectomy: A Pilot Study

  title={Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Oral Nutritional Supplements Before and After Photorefractive Keratectomy: A Pilot Study},
  author={Nikki Heidi Ong and Tracy L. Purcell and Anne-Catherine Roch-Levecq and Dorothy Wei Yun Wang and M. A. Isidro and K{\'a}tia Mantovani Bott{\'o}s and Christopher W D Heichel and David J. Schanzlin},
Purpose: To investigate the effect of omega-3 oral nutritional supplementation on corneal reepithelialization, visual acuity, and tear stability after photorefractive keratectomy (PRK). Methods: This is a prospective, randomized, single-blinded controlled therapeutic trial using omega-3 oral nutritional supplements (TheraTears Nutrition for Dry Eyes; Advanced Vision Research—Akorn, Ann Arbor, MI) conducted at our center. Eighteen healthy patients with refractive error between −1 and −8 diopters… 
Comparison of transepithelial and conventional photorefractive keratectomy in myopic and myopic astigmatism patients: a randomized contralateral trial
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Dry Eye Changes After Phacoemulsification After Using Oral Linoleinic Acid (Omega 3 Fatty Acids)
Based on the results, oral omega-3 supplements could be safely added to the postoperative protocols following phacoemulsification to reduce the incidence of postoperative dry eye syndrome.
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Clinical evidence indicates that daily oral supplementation with omega-3s statistically correlates with dry eye treatment in the general symptomatic population as well as induced sub-populations and pharmacoeconomics offers a useful and robust toolset through which analysis of cost-minimization, cost-effectiveness, and cost-utility as wellAs meta-analysis can be comparatively pursued.
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Gabapentin significantly reduced postoperative pain after PRK compared to placebo, with no increase in reported side effects.
Early postoperative pain following Epi-LASIK and photorefractive keratectomy: a prospective, comparative, bilateral study.
EPI-LASIK and PRK have similar pain on postoperative day 1, but epi-LasIK demonstrated statistically more pain than PRK on days 3 and 6.
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A better understanding of the complete cascade of events involved in the corneal wound healing process and anomalies that lead to complications is critical to improve the efficacy and safety of refractive surgical procedures.
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Dietary supplementation with omega-3 fatty acids in dry eye showed no significant effect in meibum lipid composition or aqueous tear evaporation rate, but the average tear production and tear volume was increased in the omega- 3 group as indicated by both Schirmer testing and fluorophotometry.
Inflammatory cells, refractive regression, and haze after excimer laser PRK.
Haze appears, at least in part, to be a result of fibroblast proliferation, and regression is possibly caused by slow distortion of existing tissue rather than the growth of new.
The role of omega-3 dietary supplementation in blepharitis and meibomian gland dysfunction (an AOS thesis).
  • M. Macsai
  • Medicine
    Transactions of the American Ophthalmological Society
  • 2008
This trial demonstrated a decrease in the RBC and plasma ratios of omega-6 to omega-3 in patients taking omega- 3 dietary supplementation, as compared to controls, and improvements in their overall OSDI score, TBUT, and meibum score.
Everett Kinsey Lecture. Keratocyte apoptosis in refractive surgery.
  • S. Wilson
  • Medicine, Biology
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc
  • 1998
Keratocyte apoptosis may be an initiator of the wound healing response in the cornea and control of this response has the potential to regulate wound healing in the Cornea in response to PRK or LASIK.
Keratocyte apoptosis in refractive surgery
Keratocyte apoptosis may be an initiator of the wound healing response in the cornea in response to PRK or LASIK, and control of this response has the potential to regulate wound healing in theCorneas.
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