Epithelial G protein-coupled receptor kinases regulate the initial inflammatory response during mycobacterial infection.

@article{Hkansson2013EpithelialGP,
  title={Epithelial G protein-coupled receptor kinases regulate the initial inflammatory response during mycobacterial infection.},
  author={Gisela H{\aa}kansson and Nataliya Lutay and M{\"a}rta Andersson and Oskar Hallgren and Gunilla Westergren-Thorsson and Majlis Svensson and Gabriela Godaly},
  journal={Immunobiology},
  year={2013},
  volume={218 7},
  pages={984-94}
}
The interaction between mycobacteria and epithelium is unexplored, but may determine the outcome of the infection. We have analyzed the role of two G protein-coupled receptors, CXCR1 and CXCR2 that are important regulators of many pulmonary diseases. We found that mycobacteria significantly increased the expression of both CXCR1 and CXCR2 on alveolar epithelial cells and both receptors were found to be important for neutrophil diapedesis across primary endothelial cells towards infected mucosa… CONTINUE READING