Epithelial Fluid Transport: Protruding Macromolecules and Space Charges Can Bring about Electro-Osmotic Coupling at the Tight Junctions

@article{Rubashkin2005EpithelialFT,
  title={Epithelial Fluid Transport: Protruding Macromolecules and Space Charges Can Bring about Electro-Osmotic Coupling at the Tight Junctions},
  author={Andrey A Rubashkin and Pavel Iserovich and Julio A Hernandez and Jorge Fischbarg},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={208},
  pages={251-263}
}
The purpose of the present work is to investigate whether the idea of epithelial fluid transport based on electro-osmotic coupling at the level of the leaky tight junction (TJ) can be further supported by a plausible theoretical model. We develop a model for fluid transport across epithelial layers based on electro-osmotic coupling at leaky tight junctions (TJ) possessing protruding macromolecules and fixed electrical charges. The model embodies systems of electro-hydrodynamic equations for the… CONTINUE READING