Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic

Abstract

Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice and is responsible for killing tissue-embedded larvae… (More)
DOI: 10.1016/j.chom.2017.09.006

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