Epithelial Ca2+ channels sensitive to dihydropyridines and activated by hyperpolarizing voltages.

@article{Matsunaga1994EpithelialCC,
  title={Epithelial Ca2+ channels sensitive to dihydropyridines and activated by hyperpolarizing voltages.},
  author={Hiroshi Matsunaga and Bruce A. Stanton and Frank A. Gesek and P. A. Friedman},
  journal={The American journal of physiology},
  year={1994},
  volume={267 1 Pt 1},
  pages={C157-65}
}
Parathyroid hormone (PTH) increases transcellular Ca2+ absorption in renal cortical thick ascending limbs and distal convoluted tubules (DCT). In cells isolated from these nephron segments, PTH increases Ca2+ uptake by a pathway that is sensitive to dihydropyridine-type agonists and antagonists (B. J. Bacskai and P. A. Friedman. Nature Lond. 347: 388-391, 1990). Patch-clamp techniques were used to identify Ca(2+)-permeable channels in DCT cells. Channel activity was detectable in cell-attached… CONTINUE READING

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