Epithelial Ca2+ and Mg2+ channels in kidney disease.

  title={Epithelial Ca2+ and Mg2+ channels in kidney disease.},
  author={St{\'e}phanie Th{\'e}bault and Joost G. J. Hoenderop and Ren{\'e} J M Bindels},
  journal={Advances in chronic kidney disease},
  volume={13 2},
Many physiological functions rely on the precise maintenance of body calcium (Ca2+) and magnesium (Mg2+) balance, which is tightly regulated by the concerted actions of intestinal absorption, renal reabsorption, and exchange with bone. The kidney plays an important role in the homeostasis of divalent ions. Most Ca2+ and Mg2+ reabsorption occurs in the proximal tubules and the thick ascending limb of Henle's loop via a passive paracellular pathway. At the level of the distal convoluted tubule… CONTINUE READING
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