Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer

@inproceedings{Wang2013EpithelialMesenchymalT,
  title={Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer},
  author={Hao Wang and Hongsheng Wang and Bin-Hua Zhou and Cui-Lin Li and Fan Zhang and Xian-Feng Wang and Ge Zhang and Xianzhang Bu and Shao-hui Cai and Jun Du},
  booktitle={PloS one},
  year={2013}
}
Chronic inflammation-promoted metastasis has been considered as a major challenge in cancer therapy. Pro-inflammatory cytokine TNFα can induce cancer invasion and metastasis associated with epithelial-mesenchymal transition (EMT). However, the underlying mechanisms are not entirely clear. In this study, we showed that TNFα induces EMT in human HCT116 cells and thereby promotes colorectal cancer (CRC) invasion and metastasis. TNFα-induced EMT was characterized by acquiring mesenchymal spindle… CONTINUE READING

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