Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC.

@article{Zhang2018EpithelialmesenchymalTP,
  title={Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC.},
  author={Xiaochen Zhang and Liyuan Wei and Jun Li and Jing Zheng and Shirong Zhang and Jianying Zhou},
  journal={Molecular medicine reports},
  year={2018},
  volume={19 1},
  pages={
          601-608
        }
}
Circulating tumor cells (CTCs) are closely associated with cancer metastasis in preclinical models and patients with cancer. However, to the best of the authors knowledge, it remains unknown which type of CTCs may serve the key role in cancer metastasis. The present study investigated the association between the epithelial‑mesenchymal transition (EMT) phenotype of CTCs from the peripheral blood and distant metastasis in patients with non‑small cell lung cancer (NSCLC). Expression of EMT markers… CONTINUE READING