Epithelial‐mesenchymal transition via transforming growth factor beta in pancreatic cancer is potentiated by the inflammatory glycoprotein leucine‐rich alpha‐2 glycoprotein

@inproceedings{Otsuru2019EpithelialmesenchymalTV,
  title={Epithelial‐mesenchymal transition via transforming growth factor beta in pancreatic cancer is potentiated by the inflammatory glycoprotein leucine‐rich alpha‐2 glycoprotein
},
  author={Toru Otsuru and Shogo Kobayashi and Hiromi Wada and Tsuyoshi Takahashi and Kunihito Gotoh and Yoshifumi Iwagami and Daisaku Yamada and Takehiro Noda and Tadafumi Asaoka and Satoshi Serada and Minoru Fujimoto and Hidetoshi Eguchi and Masaki Mori and Yuichirou Doki and Tetsuji Naka},
  booktitle={Cancer science},
  year={2019}
}
We previously showed that an inflammation-related, molecule leucine-rich alpha-2 glycoprotein (LRG) enhances the transforming growth factor (TGF)-β1-induced phosphorylation of Smad proteins and is elevated in patients with pancreatic ductal adenocarcinoma (PDAC). As TGF-β/Smad signaling is considered to play a key role in epithelial-mesenchymal transition (EMT), we attempted to clarify the mechanism underlying LRG-related EMT in relation to metastasis in PDAC. We cultured LRG-overexpressing… CONTINUE READING
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