Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density.

@article{Yang2007EpistaticIB,
  title={Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density.},
  author={Tielin Yang and Hui Shen and Dong-hai Xiong and Peng Xiao and Yan Guo and Yan-Fang Guo and Yao-zhong Liu and Robert Roy Recker and Hong-Wen Deng},
  journal={Annals of human genetics},
  year={2007},
  volume={71 Pt 2},
  pages={
          152-9
        }
}
Bone mineral density (BMD) is a primary risk indicator of osteoporotic fractures, which are largely determined by the actions of multiple genes. Genetic linkage studies have seldom explored epistatic interaction of genes for BMD. To evaluate potential genetic interactions for BMD at the femoral neck (FN) we conducted a variance component linkage analysis, to test epistatic effects between the genomic region containing the COL1A1 (collagen type I alpha 1) gene and the genomic regions containing… CONTINUE READING
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