Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa.

@article{Gifford2016EpistaticIB,
  title={Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa.},
  author={Danna R Gifford and Macarena Toll-Riera and R Craig MacLean},
  journal={Evolution; international journal of organic evolution},
  year={2016},
  volume={70 7},
  pages={
          1659-66
        }
}
The idea that interactions between mutations influence adaptation by driving populations to low and high fitness peaks on adaptive landscapes is deeply ingrained in evolutionary theory. Here, we investigate the impact of epistasis on evolvability by challenging populations of two Pseudomonas aeruginosa clones bearing different initial mutations (in rpoB conferring rifampicin resistance, and the type IV pili gene network) to adaptation to a medium containing l-serine as the sole carbon source… CONTINUE READING
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