Epistatic effects of immunoglobulin GM and KM allotypes on outcome of infection with hepatitis C virus.

Abstract

Immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, respectively-are associated with immune responsiveness to several infectious pathogens and with survival in certain viral epidemics. We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV) infection. To test this hypothesis, we serologically… (More)

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