Epistasis in the multiple locus symmetric viability model.

@article{Christiansen1988EpistasisIT,
  title={Epistasis in the multiple locus symmetric viability model.},
  author={Freddy Bugge Christiansen},
  journal={Journal of mathematical biology},
  year={1988},
  volume={26 6},
  pages={595-618}
}
The n-locus two-allele symmetric viability model is considered in terms of the parameters measuring the additive epistasis in fitness. The dynamics is analysed using a simple linear transformation of the gametic frequencies, and then the recurrence equations depend on the epistatic parameters and Geiringer's recombination distribution only. The model exhibits an equilibrium, the central equilibrium, where the 2n gametes are equally frequent. The transformation simplifies the stability analysis… CONTINUE READING

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