Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.

@article{RodrguezRodrguez2010EpistasisBI,
  title={Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.},
  author={Eloy Rodr{\'i}guez-Rodr{\'i}guez and Jos{\'e} Luis V{\'a}zquez-Higuera and P{\'a}scual Sanchez-Juan and Ignacio Mateo and Ana Pozueta and Ana Mart{\'i}nez-Garc{\'i}a and Ana Frank and Fernando Valdivieso and Jos{\'e} Berciano and Mar{\'i}a J Bullido and Onofre Combarros},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={21 2},
  pages={619-25}
}
Aberrant cholesterol metabolism has been implicated in Alzheimer's disease (AD). Recent findings have suggested an interaction of Niemann-Pick C1 (NPC1) and ATP-binding cassette transporter A1 (ABCA1) proteins in intracellular cholesterol transport and in maintaining cell cholesterol balance. Underexpression of NPC1 in concert with under-expression of ABCA1… CONTINUE READING