Epistasis between calpain 1 and its inhibitor calpastatin within breeds of cattle.

  title={Epistasis between calpain 1 and its inhibitor calpastatin within breeds of cattle.},
  author={William Barendse and Blair E. Harrison and Rachel Hawken and Diane M. Ferguson and J. M. Thompson and Merle B Thomas and Rowan J. Bunch},
  volume={176 4},
The calpain gene family and its inhibitors have diverse effects, many related to protein turnover, which appear to affect a range of phenotypes such as diabetes, exercise-induced muscle injury, and pathological events associated with degenerative neural diseases in humans, fertility, longevity, and postmortem effects on meat tenderness in livestock species. The calpains are inhibited by calpastatin, which binds directly to calpain. Here we report the direct measurement of epistatic interactions… CONTINUE READING
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