Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia

@inproceedings{Hill2011EpistasisBC,
  title={Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia},
  author={L. Drew Hill and Timothy P. York and Juan Pedro Kusanovic and Ricardo J. Gomez and Lindon J. Eaves and Roberto Romero and Jerome F Strauss},
  booktitle={PloS one},
  year={2011}
}
Preeclampsia is a leading cause of perinatal morbidity and mortality. This disorder is thought to be multifactorial in origin, with multiple genes, environmental and social factors, contributing to disease. One proposed mechanism is placental hypoxia-driven imbalances in angiogenic and anti-angiogenic factors, causing endothelial cell dysfunction. Catechol-O-methyltransferase (Comt)-deficient pregnant mice have a preeclampsia phenotype that is reversed by exogenous 2-methoxyestradiol (2-ME), an… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
20 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…