Epistasis and pleiotropy as natural properties of transcriptional regulation.

@article{Gibson1996EpistasisAP,
  title={Epistasis and pleiotropy as natural properties of transcriptional regulation.},
  author={Greg Gibson},
  journal={Theoretical population biology},
  year={1996},
  volume={49 1},
  pages={58-89}
}
  • Greg Gibson
  • Published 1996 in Theoretical population biology
A statistical thermodynamic model of transcriptional regulation is employed to investigate the likely effects of genetic variation on the stabilization of gene expression. The model is tailored to empirical data on the control of transcription of the hunchback gene by the morphogen Bicoid during Drosophila embryogenesis. Variable parameters include the number of binding sites for activator protein and the DNA-protein and protein-protein cooperative binding energies. Recursions are performed to… CONTINUE READING