Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.

  title={Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.},
  author={Matthew Lincoln and Sreeram V Ramagopalan and Michael J. Chao and Blanca Marcela Herrera and Gabriele C Deluca and Sarah M. Orton and David A Dyment and Adele Dessa Sadovnick and George Cornell Ebers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 18},
Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable component. Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101-HLA-DRB1*1501-HLA-DQA1*0102-HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution to MS risk. Marked linkage disequilibrium (LD) among these loci makes identification of a specific locus difficult. The once-leading candidate, HLA-DRB1*15, localizes to risk, neutral, and… CONTINUE READING


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