Epistasis: multiple sclerosis and the major histocompatibility complex.

Sreeram V. Ramagopalan, MA George C. Ebers, MD, FRCPC, FRCP, FMedSci Recent studies in multiple sclerosis (MS) have taken epistasis from speculation and expectation to the reality of its key roles in susceptibility and outcome. Bateson1 first used the term epistasis to describe the effects on a biologic trait of one gene masking another. Usage has broadened… CONTINUE READING