Episodic secretion of ACTH in rats

@article{Carnes1986EpisodicSO,
  title={Episodic secretion of ACTH in rats},
  author={Molly Carnes and Mark S. Brownfield and Ned H. Kalin and Stephanie J. Lent and Charles M. Barksdale},
  journal={Peptides},
  year={1986},
  volume={7},
  pages={219-223}
}
While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and blood sampled for up to 75 minutes at one-minute intervals beginning at 1100 hr (n=6) or 1730 hr (n=4). Sporadic low-amplitude micropulses were observed at both times of day. In… CONTINUE READING
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