Episodic outbreaks bias estimates of age-specific force of infection: a corrected method using measles as an example.

@article{Ferrari2010EpisodicOB,
  title={Episodic outbreaks bias estimates of age-specific force of infection: a corrected method using measles as an example.},
  author={Matthew J. Ferrari and Ali Djibo and Rebecca F Grais and Bryan T. Grenfell and Ottar N. Bj\ornstad},
  journal={Epidemiology and infection},
  year={2010},
  volume={138 1},
  pages={108-16}
}
Understanding age-specific differences in infection rates can be important in predicting the magnitude of and mortality in outbreaks and targeting age groups for vaccination programmes. Standard methods to estimate age-specific rates assume that the age-specific force of infection is constant in time. However, this assumption may easily be violated in the face of a highly variable outbreak history, as recently observed for acute immunizing infections like measles, in strongly seasonal settings… CONTINUE READING
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