Episodic memory on the path to Alzheimer's disease.

  title={Episodic memory on the path to Alzheimer's disease.},
  author={Michela Gallagher and Ming Teng Koh},
  journal={Current opinion in neurobiology},
  volume={21 6},
This review is focused on specific circuits of the medial temporal lobe that have become better understood in recent years for their computational properties contributing to episodic memory and to memory impairment associated with aging and other risk for AD. The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that rapidly encodes representations that are distinct from prior memories. Frank neuron loss in the… CONTINUE READING