Episodic memory, amnesia, and the hippocampal–anterior thalamic axis

@article{Aggleton1999EpisodicMA,
  title={Episodic memory, amnesia, and the hippocampal–anterior thalamic axis},
  author={John P. Aggleton and M. W. Brown},
  journal={Behavioral and Brain Sciences},
  year={1999},
  volume={22},
  pages={425 - 444}
}
By utilizing new information from both clinical and experimental (lesion, electrophysiological, and gene-activation) studies with animals, the anatomy underlying anterograde amnesia has been reformulated. The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part of an “extended hippocampal system” comprising the hippocampus, the fornix, the mamillary bodies, and the anterior thalamic nuclei. This view… 
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Looking beyond the hippocampus: old and new neurological targets for understanding memory disorders
  • J. Aggleton
  • Biology, Psychology
    Proceedings of the Royal Society B: Biological Sciences
  • 2014
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Anatomical findings now reveal that nucleus reuniens and the retrosplenial cortex provide parallel, disynaptic routes for prefrontal control of hippocampal activity, underlines the importance of redressing the balance and the value of looking beyond the hippocampus when seeking to explain failures in learning new episodic information.
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