Episodic luteinizing-hormone release in the ovariectomized female guinea pig: rapid inhibition by estrogen.

@article{Condon1988EpisodicLR,
  title={Episodic luteinizing-hormone release in the ovariectomized female guinea pig: rapid inhibition by estrogen.},
  author={Tomas Condon and M A Dykshoorn-Bosch and Matthew Kelly},
  journal={Biology of reproduction},
  year={1988},
  volume={38 1},
  pages={
          121-6
        }
}
Negative feedback of estrogen was investigated in ovariectomized female guinea pigs. Two weeks after ovariectomy, indwelling catheters were inserted into the jugular vein, and 3 days later, blood samples were taken every 10 min to determine the pattern of luteinizing hormone (LH) secretion. LH secretion in these guinea pigs was episodic, with a mean pulse period of 32 min. The mean pulse amplitude was 2.1 ng/ml, with mean plasma LH levels of 1.8 ng/ml. Twenty-five micrograms 17 beta-estradiol… CONTINUE READING
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