Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum

@article{Dere2008EpisodiclikeAP,
  title={Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum},
  author={Ekrem Dere and Armin Zlomuzica and Davide Viggiano and Lucia A. Ruocco and T. Watanabe and Adolfo Gustavo Sadile and Joseph P. Huston and M. A. De Souza-Silva},
  journal={Neuroscience},
  year={2008},
  volume={157},
  pages={532-541}
}

AMELIORATIVE EFFECTS OF HISTAMINE ON SPATIAL MEMORY DEFICITS INDUCED BY SCOPOLAMINE INFUSION INTO BILATERAL DORSAL OR VENTRAL HIPPOCAMPUS AS EVALUATED BY THE RADIAL ARM MAZE TASK

TLDR
The results of the present study indicate that histamine has different actions on cholinergic‐related memory in the the DH and VH, where histamine in the DH ameliorates spatial working memory deficits by acting on histamine H1 receptors and reference memory deficits through both H1 and H2 receptors.

Histamine facilitates GABAergic transmission in the rat entorhinal cortex: Roles of H1 and H2 receptors, Na+‐permeable cation channels, and inward rectifier K+ channels

TLDR
It is found that HA significantly increased the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) with an EC50 of 1.3 µM, but failed to significantly alter sIPSC amplitude, which may provide a cellular mechanism, at least partially, to explain the roles of HA in the brain.

Modulation of behavior by the histaminergic system: Lessons from H1R-and H2R-deficient mice

The Zinc-sensing Receptor (GPR39) Modulates Declarative Memory and Age-related Hippocampal Gene Expression in Male Mice

TLDR
The impact of GPR39 knock-out (KO) on age-related memory decline in mice of both sexes is investigated, and the effects of a G PR39 agonist on declarative memory of old animals, and its disruption in adult mice are tested.

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