Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum

@article{Dere2008EpisodiclikeAP,
  title={Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum},
  author={E. Dere and A. Zlomuzica and D. Viggiano and L. A. Ruocco and M. Souza-Silva},
  journal={Neuroscience},
  year={2008},
  volume={157},
  pages={532-541}
}
  • E. Dere, A. Zlomuzica, +2 authors M. Souza-Silva
  • Published 2008
  • Biology, Medicine
  • Neuroscience
  • We investigated episodic-like (ELM) and procedural memory (PM) in histamine H1 receptor knockout (H1R-KO) mice. In order to relate possible behavioral deficits to neurobiological changes, we examined H1R-KO and wild-type (WT) mice in terms of acetylcholine esterase (AChE) activity in subregions of the hippocampus and AChE and tyrosine hydroxylase (TH) expression in the striatum. Furthermore, we analyzed acetylcholine (ACh), 5-HT and dopamine (DA) levels, including metabolites, in the cerebellum… CONTINUE READING
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