Episodes of horizontal gene-transfer and gene-fusion led to co-existence of different metal-ion specific glyoxalase I

@inproceedings{Kaur2013EpisodesOH,
  title={Episodes of horizontal gene-transfer and gene-fusion led to co-existence of different metal-ion specific glyoxalase I},
  author={Charanpreet Kaur and Anchal Vishnoi and Thilini Udayangani Ariyadasa and Alok Bhattacharya and Sneh Lata Singla-Pareek and Sudhir Kumar Sopory},
  booktitle={Scientific reports},
  year={2013}
}
Glyoxalase pathway plays an important role in stress adaptation and many clinical disorders. The first enzyme of this pathway, glyoxalase I (GlxI), uses methylglyoxal as a substrate and requires either Ni(II)/Co(II) or Zn(II) for activity. Here we have investigated the origin of different metal ion specificities of GlxI and subsequent pattern of inheritance during evolution. Our results suggest a primitive origin of single-domain Ni dependent GlxI [Ni-GlxI]. This subsequently evolved into Zn… CONTINUE READING
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