Epirubicin and docetaxel with or without capecitabine as neoadjuvant treatment for early breast cancer: final results of a randomized phase III study (ABCSG-24).

@article{Steger2014EpirubicinAD,
  title={Epirubicin and docetaxel with or without capecitabine as neoadjuvant treatment for early breast cancer: final results of a randomized phase III study (ABCSG-24).},
  author={Guenther G. Steger and Richard Greil and Alois Lang and Margaretha Rudas and Florian Fitzal and Brigitte Mlineritsch and Bernd L. Hartmann and Rupert Bartsch and Elisabeth Melbinger and Michael Hubalek and Herbert Stoeger and Peter Christian Dubsky and Sigrun Ressler and Andreas L. Petzer and Christian F Singer and Claudia Mu\ss and Raimund Jakesz and Simon Peter Gampenrieder and Christoph Carl Zielinski and Christian Fesl and Michael Gnant},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2014},
  volume={25 2},
  pages={366-71}
}
BACKGROUND This randomized phase III trial compared pathologic complete response (pCR) rates of early breast cancer (EBC) following neoadjuvant epirubicin-docetaxel (ED)±capecitabine (C), and evaluated the addition of trastuzumab in HER2-positive tumors. PATIENTS AND METHODS Patients with invasive breast cancer (except T4d) were randomly assigned to receive six 3-weekly cycles of ED (both 75 mg/m2)±C (1000 mg/m2, twice daily, days 1-14). Patients with HER2-positive disease were further… CONTINUE READING
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First efficacy results of a randomized, open-label, phase III study of adjuvant doxorubicin plus cyclophosphamide, followed by docetaxel with or without capecitabine, in high-risk early breast cancer

  • J O’Shaughnessy, D Paul
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