Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway.

@article{Liu2008EpinephrineSE,
  title={Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway.},
  author={Xuan Liu and William Ka Kei Wu and Le Yu and Joseph Joe Yiu Sung and Gopesh Srivastava and Shu Tian Zhang and Chi-hin Cho},
  journal={Journal of cellular biochemistry},
  year={2008},
  volume={105 1},
  pages={53-60}
}
Esophageal cancer is the sixth leading causes of cancer-related death in the world. It is suggested that beta-adrenoceptor is involved in the control of cell proliferation, but its role in the pathogenesis of esophageal cancer remains unknown. We therefore studied the role of beta-adrenergic signaling in the regulation of growth of an esophageal squamous-cell carcinoma cell line HKESC-1. Results showed that both beta(1)- and beta(2)-adrenoceptors were expressed in HKESC-1 cells. Stimulation of… CONTINUE READING

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Cancer of the oesophagus in Africans in sub - Saharan Africa : Any hopes for its control ?

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