Epinephrine for Out-of-Hospital Cardiac Arrest: An Updated Systematic Review and Meta-Analysis.

@article{Aves2019EpinephrineFO,
  title={Epinephrine for Out-of-Hospital Cardiac Arrest: An Updated Systematic Review and Meta-Analysis.},
  author={Theresa Aves and Amit Sunil Chopra and Matthew Patel and Steve Lin},
  journal={Critical Care Medicine},
  year={2019}
}
OBJECTIVES To perform an updated systematic review and meta-analysis of clinical trials evaluating epinephrine for adult out-of-hospital cardiac arrest resuscitation. DATA SOURCES The search included MEDLINE, EMBASE, and Ovid Evidence-Based Medicine, clinical trial registries, and bibliographies. STUDY SELECTION Randomized and quasi-randomized controlled trials that compared the current standard dose of epinephrine to placebo, high or low dose epinephrine, any other vasopressor alone or in… 
Epinephrine before defibrillation in patients with shockable in-hospital cardiac arrest: propensity matched analysis
TLDR
Contrary to current guidelines that prioritize immediate defibrillation for in-hospital cardiac arrest due to a shockable rhythm, more than one in four patients are treated with epinephrine beforedefibrillation, which is associated with worse survival.
Relationship between the Plasma Levels of Catecholamines and Return of Spontaneous Circulation in Patients with Out-of-Hospital Cardiac Arrest
TLDR
Increased levels of Ep in the plasma may not be associated with the acquisition of ROSC in patients with OHCA, and there were no significant differences in the Plasma levels of dopamine and ADH between the two groups.
Time for Epinephrine Reboot or Give It the Boot: What Is Learned From This Meta-Analysis.
TLDR
The 2017 ECLS Working Group on thrombosis and hemostasis recommended a heparin monitoring protocol for extracorporeal membrane oxygenation as a bridge to lung transplantation, and a review of the literature supported this recommendation.
Η αποτελεσματικότητα της φυσικοθεραπείας στη σαρκοπενία και την οστεοπόρωση σε ευπαθή ηλικιωμένα άτομα
TLDR
The design of a multifaceted treatment program, which includes aerobic exercise, high resistance exercises and balance and elasticity exercises is the key to treating these geriatric diseases.

References

SHOWING 1-10 OF 16 REFERENCES
Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials.
TLDR
There was no benefit of adrenaline in survival to discharge or neurological outcomes, and there were improved rates of survival to admission and ROSC with SDA over placebo and HDA over SDA.
A Randomized Trial of Epinephrine in Out‐of‐Hospital Cardiac Arrest
TLDR
In adults with out‐of‐hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30‐day survival than theUse of placebo, but there was no significant between‐group difference in the rate of a favorable neurologic outcome.
A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest
TLDR
A randomized, double-blind trial involving 8014 patients with out-of-hospital cardiac arrest in the United Kingdom and paramedics at five National Health Service ambulance services administered either parenteral epinephrine or saline placebo, with primary outcome the rate of survival at 30 days.
COSCA (Core Outcome Set for Cardiac Arrest) in Adults: An Advisory Statement From the International Liaison Committee on Resuscitation
TLDR
Recommendations include survival, neurological function, and health-related quality of life should be measured with ≥1 tools from Health Utilities Index version 3, Short-Form 36-Item Health Survey, and EuroQol 5D-5L at 90 days and at periodic intervals up to 1 year after cardiac arrest, if resources allow.
COSCA (Core Outcome Set for Cardiac Arrest) in Adults: An Advisory Statement From the International Liaison Committee on Resuscitation.
TLDR
Recommendations that a core outcome set for reporting on effectiveness studies of cardiac arrest in adults should include survival, neurological function, and health-related quality of life should be reported as survival status and modified Rankin scale score at hospital discharge.
Combination of Vasopressin -Epinephrine as a Novel Candidate in Patients with Cardiac Arrest.
TLDR
No significant difference was observed between two groups, but survival rates after hospital discharge in group that receiving vasopressin-epinephrine was significantly higher than those patients that only got only epinephrine.
Wide variability in drug use in out-of-hospital cardiac arrest: a report from the resuscitation outcomes consortium.
TLDR
There is considerable variability among Emergency Medical Services agencies in their use of pharmacological therapy for out-of-hospital cardiac arrests which may be resolved by performing large randomized trials examining effects on survival.
Study of the Effects of Epinephrine on Cerebral Oxygenation and Metabolism During Cardiac Arrest and Resuscitation by Hyperspectral Near-Infrared Spectroscopy
TLDR
The results suggest that the effects of epinephrine diminish with successive boluses as the impact of the third bolus on brain oxygen metabolism was 24.6% ± 3.8% less than that of the first two boluses, compared with placebo.
A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TLDR
The current evidence does not support the routine use of cryotherapy after total knee arthroplasty, and the patient-centered outcomes remain underinvestigated.
Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation*
TLDR
In this model, epinephrine through its &agr;1-agonist action had adverse effects on cerebral microvascular blood flow such as to increase the severity of cerebral ischemia during CPR.
...
1
2
...