Epinephrine and its use in anaphylaxis: current issues

  title={Epinephrine and its use in anaphylaxis: current issues},
  author={K. Simons and F. E. Simons},
  journal={Current Opinion in Allergy and Clinical Immunology},
  • K. Simons, F. E. Simons
  • Published 2010
  • Medicine
  • Current Opinion in Allergy and Clinical Immunology
  • Purpose of reviewEpinephrine is a life-saving medication in the treatment of anaphylaxis, in which it has multiple beneficial pharmacologic effects. Here, we examine the evidence base for its primary role in the treatment of anaphylaxis episodes in community settings. Recent findingsWe review the practical pharmacology of epinephrine in anaphylaxis, its intrinsic limitations, and the pros and cons of different routes of administration. We provide a new perspective on the adverse effects of… CONTINUE READING
    136 Citations

    Topics from this paper

    An update on self-injectable epinephrine
    • 12
    Pharmacologic treatment of anaphylaxis: can the evidence base be strengthened?
    • F. Simons
    • Medicine
    • Current opinion in allergy and clinical immunology
    • 2010
    • 49
    Epinephrine for First-aid Management of Anaphylaxis
    • 78
    • PDF
    Contemporary issues in anaphylaxis and the evolution of epinephrine autoinjectors: What will the future bring?
    • 11
    Safety of Adrenaline Use in Anaphylaxis: A Multicentre Register
    • 16
    How to manage anaphylaxis in primary care
    • 17
    Patient perceptions of epinephrine auto-injectors: exploring barriers to use.
    • 25
    • PDF
    How incorrect is the use of adrenaline auto-injectors?
    • 1


    First-aid treatment of anaphylaxis to food: focus on epinephrine.
    • F. Simons
    • Medicine
    • The Journal of allergy and clinical immunology
    • 2004
    • 195
    Epinephrine: The Drug of Choice for Anaphylaxis-A Statement of the World Allergy Organization
    • 121
    Epinephrine absorption in children with a history of anaphylaxis.
    • 264
    Epinephrine auto-injectors: first-aid treatment still out of reach for many at risk of anaphylaxis in the community.
    • F. Simons
    • Medicine
    • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
    • 2009
    • 40
    Factors associated with repeated use of epinephrine for the treatment of anaphylaxis.
    • 49
    • PDF
    Anaphylaxis, killer allergy: long-term management in the community.
    • F. Simons
    • Medicine
    • The Journal of allergy and clinical immunology
    • 2006
    • 198